Abstract: Aiming at the difficulties in System of System (SOS) design and interface verification in lunar exploration engineering, in order to effectively solve the pre-validation problems of requirements, functions and interfaces, under the conditions of adaptive tailoring and combination for Unified Architecture Framework (UAF), the method of design and modeling for lunar exploration engineering based on UAF is proposed, which is combined with the methodology of systems engineering on the forward design ideology. Focusing on the key links in full lifecycle of lunar exploration mission, the view model systems covered with strategic, operational and resource viewpoints of related fields are established, which are taken as the core framework to carry out modeling analysis. Through requirements traceability and logical simulation iterative validation, the models can be identified problems of behavioral logic and interface matching, and be guided to complete optimization and improvement, and also it improves the rationality and effectiveness of design and modeling. The results provide a feasible reference for the SOS design of lunar exploration engineering.